Description

16α,17-Epoxy-11α-Hydroxyprogesterone Methanesulfonate is a high-purity synthetic steroid derivative, specifically a methanesulfonate salt of a modified progesterone structure. This compound is valued as a critical pharmaceutical intermediate in the synthesis of advanced steroid-based active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D and manufacturing sectors for the development of specialized corticosteroid or progestogen-based therapeutics, where precise chemical modification is essential for desired biological activity and pharmacokinetic profiles.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent corticosteroid drugs.
• Steroid API Development: Used in research and development for creating novel steroid-based active pharmaceutical ingredients with targeted therapeutic effects.
• Anti-inflammatory Agent Synthesis: Serves as a precursor in the manufacturing chain for advanced anti-inflammatory and immunosuppressant medications.
• Hormone Analog Research: Employed in academic and industrial laboratories for studying structure-activity relationships (SAR) of progesterone derivatives.
• Process Chemistry: Utilized in scale-up and process optimization for the commercial production of steroid hormones.
• Reference Standard: Can be supplied as a high-purity analytical reference standard for quality control and regulatory testing in pharmaceutical manufacturing.

Basic Information

Product Name	16α,17-Epoxy-11α-Hydroxyprogesterone Methanesulfonate
CAS No.	114327-30-9
Molecular Formula	C23H34O7S
Molecular Weight	454.58 g/mol
Synonyms	11α-Hydroxy-16α,17α-epoxypregn-4-ene-3,20-dione methanesulfonate; 16α,17α-Epoxy-11α-hydroxyprogesterone methanesulfonate; 11α-Hydroxy-16α,17α-epoxyprogesterone methanesulfonate; Pregna-4-ene-3,20-dione, 16,17-epoxy-11-hydroxy-, methanesulfonate (1:1), (11α,16α)-; 16α,17α-Epoxy-11α-hydroxypregn-4-ene-3,20-dione methanesulfonate
EINECS	Contact for details

Quality Control

Our 16α,17-Epoxy-11α-Hydroxyprogesterone Methanesulfonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) documenting all test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.