Description

Methyl 3,3,3-Trifluoro-2-Hydroxy-2-(1H-Indol-3-Yl)Propanoate is a high-value, fluorinated indole derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both a trifluoromethyl group and an indole moiety, provides significant advantages for modulating the biological activity, metabolic stability, and lipophilicity of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated active ingredients for crop protection products, enhancing their efficacy and environmental profile.
• Chemical Biology & Proteomics: Serves as a valuable scaffold or probe in the study of enzyme mechanisms and protein-ligand interactions due to its distinctive fluorine signature.
• Material Science Research: Investigated as a precursor for specialty fluorinated polymers or organic electronic materials with tailored properties.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development in asymmetric synthesis and fluorine chemistry.

Basic Information

Product Name	Methyl 3,3,3-Trifluoro-2-Hydroxy-2-(1H-Indol-3-Yl)Propanoate
CAS No.	114125-58-5
Molecular Formula	C₁₂H₁₀F₃NO₃
Molecular Weight	273.21 g/mol
Synonyms	Methyl 3,3,3-Trifluoro-2-hydroxy-2-(1H-indol-3-yl)propanoate; 3,3,3-Trifluoro-2-hydroxy-2-(1H-indol-3-yl)propanoic Acid Methyl Ester; 2-Hydroxy-2-(1H-indol-3-yl)-3,3,3-trifluoropropanoic Acid Methyl Ester; Methyl 2-Hydroxy-2-(indol-3-yl)-3,3,3-trifluoropropionate; Trifluoromethyl Indole Hydroxy Propanoate Methyl Ester; (2R/S)-Methyl 3,3,3-trifluoro-2-hydroxy-2-(1H-indol-3-yl)propanoate (racemate)
EINECS	Contact for details

Quality Control

Our production of Methyl 3,3,3-Trifluoro-2-Hydroxy-2-(1H-Indol-3-Yl)Propanoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are characterized using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Chiral Purity (if applicable)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.