Description

Fmoc-Pro-Odhbt CAS NO 114119-85-6 is a specialized, protected amino acid derivative widely used as a key building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the efficient and controlled incorporation of proline into peptide chains while preventing unwanted side reactions. This high-purity reagent is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the sequential coupling of proline residues in automated and manual peptide synthesis protocols.
• Pharmaceutical Research & Development: Used in the discovery and production of peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates for targeted drug delivery systems.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Proteomics and Biochemical Studies: Utilized in the synthesis of custom peptide substrates, antigens, or probes for enzymatic assays and antibody production.
• Material Science: Can be incorporated into peptide-based polymers or biomaterials to impart specific structural or functional properties.

Basic Information

Product Name	Fmoc-Pro-Odhbt
CAS No.	114119-85-6
Molecular Formula	C26H20N2O6
Molecular Weight	456.45 g/mol
Synonyms	Fmoc-Pro-ODhbt; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline 3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl Ester; Fmoc-L-Proline 3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl Ester; Fmoc-Proline ODhbt Ester; 1,2,3-Benzotriazin-4(3H)-one, 3-[[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl]oxy]-3,4-dihydro-; Fmoc-Pro-OBt (common abbreviation); Fmoc-Protected Proline Active Ester
EINECS	Contact for details

Quality Control

Our Fmoc-Pro-Odhbt is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.