Description

(6-Chlorohex-1-Ynyl)Trimethylsilane is a versatile organosilicon building block featuring both a terminal alkyne and a reactive chloroalkyl group, protected by a trimethylsilyl (TMS) moiety. This unique bifunctional structure makes it a critical intermediate for constructing complex molecular architectures in advanced organic synthesis and materials science. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries for applications requiring precise carbon chain elongation and functional group manipulation.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for carbon-carbon bond formation via Sonogashira and other cross-coupling reactions.
• Agrochemical Synthesis: Serves as a key precursor for creating novel herbicides, fungicides, and plant growth regulators that require specific alkyne-functionalized side chains.
• Material Science & Polymer Chemistry: Employed in the production of specialty polymers, dendrimers, and silicon-containing hybrid materials where the alkyne group enables click chemistry (e.g., Huisgen cycloaddition).
• Liquid Crystal & OLED Research: Acts as a building block for synthesizing organic semiconductors and liquid crystal molecules with tailored electronic and optical properties.
• Chemical Biology & Bioconjugation: Utilized for labeling biomolecules (proteins, nucleic acids) due to the bio-orthogonal reactivity of the terminal alkyne group.
• Organic Synthesis Reagent: Functions as a protected alkyne synthon for multi-step synthetic sequences, allowing for the sequential deprotection and functionalization of the alkyne and alkyl chloride sites.

Basic Information

Product Name	(6-Chlorohex-1-Ynyl)Trimethylsilane
CAS No.	113964-33-3
Molecular Formula	C9H17ClSi
Molecular Weight	188.77 g/mol
Synonyms	6-Chloro-1-hexynyltrimethylsilane; 1-Chloro-6-(trimethylsilyl)hex-1-yne; Trimethyl(6-chloro-1-hexyn-1-yl)silane; 6-Chloro-1-hexyne, 1-trimethylsilyl-; (6-Chloro-1-hexyn-1-yl)trimethylsilane; TMS-Protected 6-Chloro-1-hexyne; Chlorohexynyltrimethylsilane
EINECS	Contact for details

Quality Control

Our (6-Chlorohex-1-Ynyl)Trimethylsilane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and process chemistry. Each lot is analyzed via GC, NMR, and other appropriate analytical techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.