Description

Methyl (S)-2-(tert-Butoxycarbonylamino)-3-(4-Iodophenyl)Propanoate is a high-purity, non-natural amino acid derivative featuring a chiral center and a protected amine group. This compound is a critical chiral building block for the synthesis of complex bioactive molecules, offering precise stereochemical control. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing peptide-based therapeutics, enzyme inhibitors, and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide drugs, enzyme inhibitors, and other active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used in research and production of inhibitors targeting specific proteases, leveraging the iodophenyl moiety for molecular recognition.
• Peptidomimetics: Serves as a constrained amino acid analog in the design of peptidomimetic compounds with enhanced metabolic stability.
• Diagnostic Agent Synthesis: The iodine atom provides a handle for radiolabeling (e.g., with I-125) for use in diagnostic imaging or research tracers.
• Chemical Biology & Proteomics: Employed as a tool compound or a building block for activity-based probes to study enzyme function.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective synthesis campaigns.

Basic Information

Product Name	Methyl (S)-2-(tert-Butoxycarbonylamino)-3-(4-Iodophenyl)Propanoate
CAS No.	113850-76-3
Molecular Formula	C15H20INO4
Molecular Weight	405.23 g/mol
Synonyms	(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(4-iodophenyl)propanoate; Boc-4-Iodo-L-phenylalanine methyl ester; Boc-L-4-Iodophenylalanine methyl ester; (S)-2-(tert-Butoxycarbonylamino)-3-(4-iodophenyl)propionic acid methyl ester; N-Boc-4-iodo-L-phenylalanine methyl ester; Methyl N-Boc-4-iodo-L-phenylalaninate; N-α-Boc-4-iodo-L-phenylalanine methyl ester; Boc-Phe(4-I)-OMe
EINECS	Contact for details

Quality Control

Our Methyl (S)-2-(tert-Butoxycarbonylamino)-3-(4-Iodophenyl)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.