Description

5-Diethoxyphosphinyl-2-Hydroxy-4-Oxopentanoic Acid Methyl Ester is a high-value organophosphorus intermediate with a unique bifunctional structure. This compound matters for its critical role in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by fine chemical manufacturers and R&D laboratories engaged in creating novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where precise molecular construction is paramount.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting metabolic and neurological pathways.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its phosphonate moiety.
• Peptidomimetic Research: Serves as a precursor for non-hydrolyzable phosphonate analogs of amino acids and peptides in medicinal chemistry.
• Chemical Biology Probes: Employed in the development of enzyme inhibitors and activity-based probes for studying biochemical mechanisms.
• Ligand Synthesis for Catalysis: Utilized in the preparation of specialized phosphonate-containing ligands for metal-catalyzed reactions.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of novel polymeric materials with specific functional properties.

Basic Information

Product Name	5-Diethoxyphosphinyl-2-Hydroxy-4-Oxopentanoic Acid Methyl Ester
CAS No.	113848-01-4
Molecular Formula	C10H19O7P
Molecular Weight	282.23 g/mol
Synonyms	Methyl 5-(diethoxyphosphinyl)-2-hydroxy-4-oxopentanoate; 2-Hydroxy-4-oxo-5-phosphonopentanoic acid methyl ester, diethyl ester; Diethyl (2-hydroxy-4-oxo-5-methoxycarbonylpentyl)phosphonate; Phosphono-Leu-OH(OMe) diethyl ester analog; 4-Oxo-2-hydroxy-5-phosphonopentanoic acid methyl ester diethyl ester
EINECS	Contact for details

Quality Control

Every batch of 5-Diethoxyphosphinyl-2-Hydroxy-4-Oxopentanoic Acid Methyl Ester is produced under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.