Description

1,4-Dioxaspiro[4.5]Decane-2-Methanol, (R)- is a high-value chiral building block and intermediate in organic synthesis, distinguished by its spirocyclic acetal-protected diol functionality. Its primary commercial value lies in its role as a precursor for the synthesis of complex, stereochemically defined molecules, particularly in the pharmaceutical sector. This compound is essential for researchers and process chemists in fine chemical, agrochemical, and advanced material industries who require enantiomerically pure intermediates for asymmetric synthesis.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of active pharmaceutical ingredients (APIs), especially those requiring specific stereochemistry.
• Asymmetric Synthesis: Used as a starting material or auxiliary in catalytic asymmetric reactions to construct complex molecular architectures.
• Agrochemical Research: Serves as a building block for developing enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Utilized in the synthesis of novel chiral ligands and organocatalysts for stereoselective transformations.
• Fine Chemical Production: Intermediate for manufacturing specialty chemicals, flavors, and fragrances where optical purity is critical.
• Material Science: Potential monomer or cross-linker for creating polymers with specific chiral or structural properties.

Basic Information

Product Name	1,4-Dioxaspiro[4.5]Decane-2-Methanol, (R)-
CAS No.	113798-80-4
Molecular Formula	C10H18O3
Molecular Weight	186.25 g/mol
Synonyms	(R)-1,4-Dioxaspiro[4.5]decane-2-methanol; (R)-2-(Hydroxymethyl)-1,4-dioxaspiro[4.5]decane; (R)-Spiroacetal-protected Diol; (R)-Cyclohexanone ethylene ketal methanol; (R)-2-Hydroxymethyl-1,4-dioxaspiro[4.5]decane; (R)-1,4-Dioxaspiro[4.5]decan-2-ylmethanol
EINECS	Contact for details

Quality Control

Our 1,4-Dioxaspiro[4.5]Decane-2-Methanol, (R)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Products undergo rigorous analytical testing, including chiral HPLC, NMR, and GC, to confirm identity, purity, and optical rotation. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.