Description

Boc-4-Hydroxy-L-Pyrrolidine Lactone is a protected chiral intermediate of significant value in synthetic organic chemistry. This compound matters for its role as a key building block in the synthesis of complex pharmaceutical molecules, particularly those requiring a defined stereocenter. Pharmaceutical researchers and fine chemical manufacturers need it for developing active pharmaceutical ingredients (APIs), especially in the areas of protease inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used in the research and production of protease inhibitors, a major class of antiviral and anticancer therapeutics.
• Peptidomimetics Synthesis: Serves as a constrained proline analog for constructing peptidomimetic scaffolds in medicinal chemistry.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective chemical transformations.
• Bioconjugation Chemistry: Can be utilized in the development of linker molecules for antibody-drug conjugates (ADCs) and other bioconjugates.
• Academic & Industrial R&D: A valuable reagent for research in synthetic methodology and new chemical entity discovery.

Basic Information

Product Name	Boc-4-Hydroxy-L-Pyrrolidine Lactone
CAS No.	113775-22-7
Molecular Formula	C9H15NO4
Molecular Weight	201.22 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid lactone; (3S)-1-[(1,1-Dimethylethoxy)carbonyl]-3-hydroxy-2-pyrrolidinone; 1-Boc-4-hydroxy-L-proline lactone; 1-N-Boc-4-hydroxy-L-proline lactone; (S)-1-Boc-4-hydroxy-2-pyrrolidinone; tert-Butyl (S)-4-hydroxy-2-oxopyrrolidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-hydroxy-L-proline lactone
EINECS	Contact for details

Quality Control

Our Boc-4-Hydroxy-L-Pyrrolidine Lactone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.