Description

(R)-Lormetazepam CAS NO 113679-56-4 is the single enantiomer of the benzodiazepine derivative Lormetazepam, characterized by its specific stereochemistry at the chiral center. This compound is of significant interest in advanced pharmaceutical research and development, particularly for studying stereoselective pharmacological effects and metabolism. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing or analyzing enantiomerically pure active pharmaceutical ingredients (APIs) and their intermediates.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Metabolite and Impurity Profiling: Used in the identification and quantification of specific enantiomeric impurities or metabolites in bulk drug substances and finished dosage forms.
• Preclinical Pharmacological Research: Employed in in-vitro and in-vivo studies to investigate the distinct biological activity, receptor binding affinity, and toxicological profile of the (R)-enantiomer.
• Chiral Synthesis Intermediate: Acts as a key building block or precursor in the asymmetric synthesis of more complex, stereochemically defined molecules for medicinal chemistry programs.
• Regulatory and Forensic Analysis: Essential for compliance testing and forensic science applications requiring precise identification and differentiation of stereoisomers.

Basic Information

Product Name	(R)-Lormetazepam
CAS No.	113679-56-4
Molecular Formula	C₁₆H₁₂Cl₂N₂O₂
Molecular Weight	335.18 g/mol
Synonyms	(R)-Lormetazepam; (R)-Enantiomer of Lormetazepam; (5R)-6-(2-Chlorophenyl)-9-chloro-2-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-one; (R)-(-)-Lormetazepam; Dextro-Lormetazepam; Lormetazepam Enantiomer R; Lormetazepam Impurity R
EINECS	Contact for details

Quality Control

Our (R)-Lormetazepam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure identity, potency, and purity meet exacting standards for research use. A detailed Certificate of Analysis (COA) providing batch-specific results for assay, enantiomeric excess, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.