Description

(S)-Lormetazepam is the S-enantiomer of lormetazepam, a high-purity benzodiazepine derivative. This specific stereoisomer is of significant interest for advanced pharmaceutical research and development, particularly in studying receptor-specific interactions and metabolic pathways. It serves as a critical intermediate and reference standard for researchers and manufacturers in the pharmaceutical and fine chemical sectors, enabling the development of novel therapeutic agents and analytical methods.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of advanced active pharmaceutical ingredients (APIs) and potential new chemical entities.
• Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Metabolic & Pharmacological Research: Employed in preclinical studies to investigate the stereoselective metabolism, pharmacokinetics, and pharmacodynamics of benzodiazepine compounds.
• Process Chemistry & Development: Utilized in route scouting and optimization for the asymmetric synthesis of complex molecules in fine chemical and API manufacturing.
• Academic Research: A valuable compound for university and institutional research into neuroscience, medicinal chemistry, and enantioselective catalysis.

Basic Information

Product Name	(S)-Lormetazepam
CAS No.	113679-54-2
Molecular Formula	C₁₆H₁₂Cl₂N₂O₂
Molecular Weight	335.18 g/mol
Synonyms	(S)-Lormetazepam; (S)-(-)-Lormetazepam; (S)-7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one; Lormetazepam S-enantiomer; (3S)-7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; EN 1028-S; (S)-(-)-EN 1028
EINECS	Contact for details

Quality Control

Our (S)-Lormetazepam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development purposes. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.