Description

2-Propanol, 1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-, (2S)- (9Ci) is a chiral, silyl-protected alcohol derivative, a high-value intermediate in sophisticated organic synthesis. Its primary value lies in its role as a versatile protecting group for hydroxyl functions, enabling complex multi-step reactions with high stereochemical fidelity. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and advanced materials sectors who require precise control over molecular architecture.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of chiral active pharmaceutical ingredients (APIs), particularly for complex molecules like antivirals, antibiotics, and oncology drugs.
• Asymmetric Synthesis: Used in stereoselective reactions to construct specific enantiomers, crucial for developing therapeutics with targeted efficacy and reduced side effects.
• Peptide & Carbohydrate Chemistry: Serves as a protecting group for hydroxyl amino acids (e.g., serine, threonine) and sugar derivatives during solid-phase and solution-phase synthesis.
• Natural Product Synthesis: Integral to the total synthesis of complex natural products with multiple stereocenters, where selective protection and deprotection are required.
• Process Chemistry Development: Employed in route scouting and optimization for scalable manufacturing of fine chemicals and advanced intermediates.
• Material Science Research: Potential precursor for creating chiral ligands, catalysts, or functionalized surfaces with specific stereochemical properties.

Basic Information

Product Name	2-Propanol, 1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-, (2S)- (9Ci)
CAS No.	113534-13-7
Molecular Formula	C9H22O2Si
Molecular Weight	190.36 g/mol
Synonyms	(2S)-1-[(tert-Butyldimethylsilyl)oxy]-2-propanol; (S)-1-(tert-Butyldimethylsilyloxy)-2-propanol; (S)-1-((tert-Butyldimethylsilyl)oxy)propan-2-ol; (S)-1-(TBDMSO)propan-2-ol; (S)-TBDMS-protected isopropanol; (S)-1-Hydroxy-2-(tert-butyldimethylsilyloxy)propane; L-1-(tert-Butyldimethylsilyloxy)-2-propanol; Chiral TBDMS ether of isopropanol
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Quality is verified through comprehensive analytical methods including Chiral HPLC, GC, and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (assay), enantiomeric excess (ee), and impurity profile. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (Assay by GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF Titration)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.