Description

(Z)-4-((tert-Butyldimethylsilyl)Oxy)But-2-En-1-Ol is a high-value, protected alcohol intermediate featuring a silyl ether group and an allylic alcohol moiety. This compound is critical for synthetic organic chemistry, serving as a versatile building block for the stereoselective construction of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), fine chemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and bioactive molecules.
• Asymmetric Synthesis: Used in stereocontrolled reactions, such as Sharpless asymmetric epoxidation or other transition metal-catalyzed transformations, to introduce specific stereochemistry.
• Natural Product Synthesis: Serves as a crucial fragment for constructing segments of natural products with defined (Z)-alkene geometry and protected hydroxyl functionality.
• Polymer & Material Science: Acts as a functional monomer or cross-linking agent for creating specialty polymers with tailored properties.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds or molecular probes for studying biological pathways.
• Agrochemical Research: Used as an intermediate in the development of novel pesticides or plant growth regulators requiring specific stereochemistry.

Basic Information

Product Name	(Z)-4-((tert-Butyldimethylsilyl)Oxy)But-2-En-1-Ol
CAS No.	113123-37-8
Molecular Formula	C10H22O2Si
Molecular Weight	202.37 g/mol
Synonyms	(Z)-4-[(tert-Butyldimethylsilyl)oxy]-2-buten-1-ol; (Z)-4-(tert-Butyldimethylsiloxy)but-2-en-1-ol; (Z)-4-(TBDMSO)but-2-en-1-ol; (Z)-TBDMS Protected But-2-ene-1,4-diol (mono-TBDMS ether); (2Z)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-buten-1-ol; (Z)-4-Hydroxy-2-butenyl tert-butyldimethylsilyl ether; (Z)-4-O-TBDMS-but-2-ene-1-ol
EINECS	Contact for details

Quality Control

Our (Z)-4-((tert-Butyldimethylsilyl)Oxy)But-2-En-1-Ol is manufactured under strict quality control protocols to ensure high chemical purity and stereochemical integrity, critical for sensitive synthetic applications. Each batch is analyzed via advanced chromatographic and spectroscopic methods (HPLC, GC, NMR) to confirm identity, isomeric purity ((Z)-isomer content), and potency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation upon prolonged exposure to air.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
(Z)-Isomer Content	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.