Description

(2S)-2-(3-Aminopropanoylamino)-3-[4-[Bis(2-Chloroethyl)Amino]Phenyl]Propanoic Acid is a specialized synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound matters for its role as a key building block in the synthesis of complex, targeted therapeutic agents, particularly in oncology. Pharmaceutical R&D laboratories and fine chemical manufacturers need this high-purity intermediate to develop novel drug candidates and reference standards.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of targeted anti-cancer agents and other specialized therapeutics.
• Research & Development: Used in academic and industrial laboratories for investigating new pharmacological pathways and structure-activity relationships (SAR).
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Bioconjugation Chemistry: Utilized in the development of antibody-drug conjugates (ADCs) and other targeted drug delivery systems due to its reactive functional groups.
• Process Chemistry: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under GMP conditions.

Basic Information

Product Name	(2S)-2-(3-Aminopropanoylamino)-3-[4-[Bis(2-Chloroethyl)Amino]Phenyl]Propanoic Acid
CAS No.	112710-37-9
Molecular Formula	C₁₆H₂₃Cl₂N₃O₃
Molecular Weight	376.28 g/mol
Synonyms	L-Phenylalanine, N-[3-amino-1-oxopropyl]-4-[bis(2-chloroethyl)amino]-; 4-[Bis(2-chloroethyl)amino]-L-phenylalanine-β-alaninamide; Melphalan-β-alaninamide; Chlorambucil Amide Derivative; NSC-Derivative; L-Melphalan Amide Analog; (S)-2-(3-Aminopropanamido)-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our production of (2S)-2-(3-Aminopropanoylamino)-3-[4-[Bis(2-Chloroethyl)Amino]Phenyl]Propanoic Acid adheres to stringent quality protocols suitable for pharmaceutical intermediate applications. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing comprehensive testing results, including HPLC purity and chiral purity, are provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.