Description

(R)-Methyl 2-((tert-Butoxycarbonyl)Amino)-3-((tert-Butyldimethylsilyl)Oxy)Propanoate CAS NO 112418-19-6 is a high-purity, chiral building block featuring orthogonal protecting groups for the amine and alcohol functionalities. This compound is critical for the stereoselective synthesis of complex molecules, offering chemists precise control over molecular architecture. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), peptides, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used for the controlled incorporation of serine or related amino acid derivatives into peptide chains with defined stereochemistry.
• Asymmetric Synthesis: Serves as a versatile starting material or intermediate in catalytic asymmetric transformations to construct complex chiral centers.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) and tert-butyldimethylsilyl (TBDMS) groups allow for sequential, orthogonal deprotection, enabling sophisticated synthetic routes.
• Process Chemistry & Scale-up: Suitable for development from laboratory-scale research to pilot plant and commercial manufacturing of advanced intermediates.
• Academic & Industrial R&D: Essential for medicinal chemistry programs and methodological research in organic synthesis.

Basic Information

Product Name	(R)-Methyl 2-((tert-Butoxycarbonyl)Amino)-3-((tert-Butyldimethylsilyl)Oxy)Propanoate
CAS No.	112418-19-6
Molecular Formula	C15H31NO5Si
Molecular Weight	333.50 g/mol
Synonyms	Methyl (R)-2-[(tert-butoxycarbonyl)amino]-3-[(tert-butyldimethylsilyl)oxy]propanoate; (R)-Methyl 2-(Boc-amino)-3-(TBDMS-oxy)propionate; Boc-Ser(TBDMS)-OMe; N-Boc-O-TBDMS-L-serine methyl ester; (2R)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]-3-[[tert-butyl(dimethyl)silyl]oxy]propanoic acid methyl ester; (R)-3-((tert-Butyldimethylsilyl)oxy)-2-((tert-butoxycarbonyl)amino)propanoic acid methyl ester; L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-[1,1-dimethylethyl)dimethylsilyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our production of (R)-Methyl 2-((tert-Butoxycarbonyl)Amino)-3-((tert-Butyldimethylsilyl)Oxy)Propanoate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for chiral purity and assay, to ensure compliance with customer specifications and internal standards. A detailed Certificate of Analysis (COA) documenting identity, purity, and chiral excess is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.