Description

3-Chloro-D-Alanine Methyl Ester,Hydrochloride is a specialized chiral building block and intermediate of significant interest in advanced organic synthesis. This compound matters for its role in the preparation of modified amino acids and peptides, enabling the introduction of chlorine functionality for structure-activity relationship studies. Pharmaceutical researchers and fine chemical manufacturers need it for developing novel active pharmaceutical ingredients (APIs), enzyme inhibitors, and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel antibiotics, enzyme inhibitors, and other therapeutic agents.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate chlorinated alanine derivatives into peptide chains.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly those involving alanine racemase or other PLP-dependent enzymes.
• Agrochemical Synthesis: An intermediate in the development of advanced herbicides or pesticides with chiral specificity.
• Proteomics & Labeling: Potential use in the design of activity-based probes (ABPs) or affinity labels for target protein identification.
• Material Science: A building block for specialized polymers or dendrimers with unique functional properties.

Basic Information

Product Name	3-Chloro-D-Alanine Methyl Ester,Hydrochloride
CAS No.	112346-82-4
Molecular Formula	C4H9Cl2NO2
Molecular Weight	198.03 g/mol
Synonyms	Methyl (2R)-2-Amino-3-chloropropanoate Hydrochloride; D-3-Chloroalanine Methyl Ester Hydrochloride; (R)-Methyl 2-Amino-3-chloropropanoate Hydrochloride; Methyl (R)-2-Amino-3-chloropropionate Hydrochloride; (R)-Methyl 3-Chloroalaninate Hydrochloride; 3-Chloro-D-alanine methyl ester HCl; D-β-Chloroalanine Methyl Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Chloro-D-Alanine Methyl Ester,Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.