Description

o-tert-Butyldimethylsilyl-n-T-Butoxycarbonyl-L-Tyrosine, Methyl Ester is a sophisticated, dual-protected derivative of the essential amino acid L-Tyrosine, designed for advanced synthetic applications. This compound is critical for researchers and manufacturers who require high-purity, chemically stable intermediates to ensure the success of complex multi-step syntheses. It is primarily utilized in the pharmaceutical industry for the development of peptide-based therapeutics and active pharmaceutical ingredients (APIs), where precise molecular control is paramount.

Application

• Peptide Synthesis Intermediate: Serves as a key building block in solid-phase and solution-phase peptide synthesis (SPPS), particularly for introducing protected tyrosine residues.
• Pharmaceutical Research & Development: Used in the R&D of novel peptide drugs, hormone analogs, and other bioactive molecules requiring specific tyrosine modifications.
• API (Active Pharmaceutical Ingredient) Manufacturing: Employed as a critical intermediate in the commercial-scale production of complex peptide-based APIs.
• Bioconjugation Chemistry: Facilitates the site-specific modification of peptides and proteins for drug delivery systems and diagnostic probes.
• Academic & Institutional Research: A valuable reagent for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies in university and institutional labs.

Basic Information

Product Name	o-tert-Butyldimethylsilyl-n-T-Butoxycarbonyl-L-Tyrosine, Methyl Ester
CAS No.	112196-57-3
Molecular Formula	C21H35NO5Si
Molecular Weight	409.60 g/mol
Synonyms	Boc-Tyr(OTBS)-OMe; Boc-L-Tyrosine(O-tert-butyldimethylsilyl)-methyl ester; Methyl N-(tert-butoxycarbonyl)-O-[tert-butyl(dimethyl)silyl]-L-tyrosinate; Boc-Tyr(TBDMS)-OMe; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-[4-[[tert-butyl(dimethyl)silyl]oxy]phenyl]propanoic acid methyl ester; N-Boc-O-TBDMS-L-tyrosine methyl ester; L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-O-[1,1-dimethylethyl)dimethylsilyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our production of o-tert-Butyldimethylsilyl-n-T-Butoxycarbonyl-L-Tyrosine, Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive pharmaceutical applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under inert atmosphere when appropriate for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Specific range available on COA
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.