Description

Cyclobutanecarboxylic Acid, 2-(Hydroxymethyl)-3-Oxo-, Methyl Ester, trans- (9Ci) is a high-purity, synthetically valuable chiral building block characterized by its unique cyclobutane ring fused with a β-keto ester moiety. This compound matters for its role as a versatile intermediate in the synthesis of complex pharmaceutical molecules and advanced materials, offering precise stereochemical control. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides with enhanced efficacy and selectivity.
• Organic Synthesis Building Block: Serves as a precursor for complex natural product synthesis and the preparation of novel heterocyclic compounds.
• Material Science Research: Investigated as a monomer or cross-linking agent for developing polymers with specific thermal or mechanical properties.
• Asymmetric Catalysis: Employed as a substrate or ligand precursor in catalytic reactions to induce chirality in target molecules.
• Academic & Industrial R&D: Essential for methodological studies in organic chemistry and for exploring new synthetic pathways in process chemistry.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 2-(Hydroxymethyl)-3-Oxo-, Methyl Ester, trans- (9Ci)
CAS No.	112139-40-9
Molecular Formula	C8H12O4
Molecular Weight	172.18 g/mol
Synonyms	trans-2-(Hydroxymethyl)-3-oxocyclobutanecarboxylic acid methyl ester; Methyl trans-2-(hydroxymethyl)-3-oxocyclobutanecarboxylate; (1R,2S)-rel-2-(Hydroxymethyl)-3-oxocyclobutanecarboxylic Acid Methyl Ester; (1S,2R)-rel-2-(Hydroxymethyl)-3-oxocyclobutanecarboxylic Acid Methyl Ester; 3-Oxocyclobutanecarboxylic acid, 2-(hydroxymethyl)-, methyl ester, trans-; Cyclobutanecarboxylic acid, 2-(hydroxymethyl)-3-oxo-, methyl ester, (1R,2S)-rel-
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 2-(Hydroxymethyl)-3-Oxo-, Methyl Ester, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.