Description

(R)-α-[[(4-Nitrophenyl)Sulfonyl]Oxy]Cyclohexanebutanoic Acid Ethyl Ester is a high-purity chiral intermediate of significant importance in advanced organic synthesis. Its core value lies in its role as a key building block for the development of enantiomerically pure pharmaceuticals and bioactive compounds. This product is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require a reliable source of high-quality, stereochemically defined intermediates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) requiring specific (R)-configuration.
• Asymmetric Synthesis: Used in the construction of complex molecules for medicinal chemistry research and drug discovery programs.
• Agrochemical Development: Serves as a precursor in the synthesis of chiral pesticides, herbicides, or plant growth regulators.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where enantiopurity is crucial.
• Catalyst & Ligand Synthesis: Potential use in the preparation of chiral catalysts or ligands for asymmetric catalysis.
• Academic & Industrial R&D: A valuable reagent for methodological development and process optimization in synthetic organic chemistry.

Basic Information

Product Name	(R)-α-[[(4-Nitrophenyl)Sulfonyl]Oxy]Cyclohexanebutanoic Acid Ethyl Ester
CAS No.	112110-45-9
Molecular Formula	C18H25NO7S
Molecular Weight	399.46 g/mol
Synonyms	(R)-α-((4-Nitrophenylsulfonyl)oxy)cyclohexanebutanoic acid ethyl ester; Ethyl (R)-4-((((4-nitrophenyl)sulfonyl)oxy)methyl)cyclohexanebutanoate; (R)-Ethyl 4-((((4-nitrophenyl)sulfonyl)oxy)methyl)cyclohexanebutanoate; (R)-α-Tosyloxy Cyclohexanebutanoic Acid Ethyl Ester (p-nitro variant); (R)-Ethyl α-((4-nitrobenzenesulfonyl)oxy)cyclohexanebutyrate; (R)-Ethyl 4-((tosyloxy)methyl)cyclohexanebutanoate (nitro derivative); (R)-O-(4-Nitrobenzenesulfonyl) Cyclohexanebutanoic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our (R)-α-[[(4-Nitrophenyl)Sulfonyl]Oxy]Cyclohexanebutanoic Acid Ethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical purity, and identity confirmation. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.