Description

(R)-2,2-Dimethyl-1,3-Dioxolane-4-Acetic Acid, Methyl Ester is a high-value chiral building block and synthetic intermediate of significant importance in fine chemical synthesis. Its core value proposition lies in its role as a protected form of (R)-glyceraldehyde acetonide, providing a versatile and enantiomerically pure starting material for complex molecule construction. This compound is essential for research and production in the pharmaceutical and agrochemical industries, where precise stereochemistry is critical for biological activity. Its reliable quality and consistent performance make it a key component for chemists developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor in the synthesis of antiviral drugs, protease inhibitors, and other active pharmaceutical ingredients (APIs) requiring specific (R)-configuration.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators where the stereochemistry impacts efficacy and environmental profile.
• Fine Chemical Production: Serves as a versatile building block for synthesizing complex natural products, flavors, fragrances, and specialty polymers.
• Asymmetric Catalysis & Ligand Synthesis: Employed in the development of chiral catalysts and ligands for stereoselective transformations in academic and industrial research.
• Biochemical Research: Used as a standard or reagent in studies involving carbohydrate chemistry, enzyme mechanisms, and metabolic pathway analysis.

Basic Information

Product Name	(R)-2,2-Dimethyl-1,3-Dioxolane-4-Acetic Acid, Methyl Ester
CAS No.	112031-10-4
Molecular Formula	C8H14O4
Molecular Weight	174.19 g/mol
Synonyms	(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-acetic acid methyl ester; Methyl (R)-2,2-dimethyl-1,3-dioxolane-4-acetate; (R)-Glyceraldehyde acetonide methyl ester; (4R)-2,2-Dimethyl-1,3-dioxolane-4-acetic acid methyl ester; (R)-(-)-Glyceraldehyde acetonide methyl ester; (R)-Acetonide of methyl glycerate; Methyl (R)-2,3-O-isopropylideneglycerate
EINECS	Contact for details

Quality Control

Our (R)-2,2-Dimethyl-1,3-Dioxolane-4-Acetic Acid, Methyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR for structural confirmation, and GC for purity assessment. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical specifications to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]20/D	-15° to -18° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.