Description

Proline, 5-Ethenyl-, Ethyl Ester, cis- (9Ci) is a specialized proline derivative, a chiral non-proteinogenic amino acid ester of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and industrial R&D departments focused on medicinal chemistry, asymmetric synthesis, and the production of peptidomimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a constrained scaffold for designing and synthesizing novel peptidomimetics and drug candidates with improved metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective reactions to construct complex molecules with high enantiomeric purity.
• Bioconjugation & Probe Development: Useful for modifying peptides or creating fluorescent or affinity probes for biochemical and diagnostic applications.
• Agrochemical Research: Potential intermediate in the synthesis of novel, chiral agrochemicals such as herbicides or fungicides.
• Academic & Industrial R&D: Serves as a valuable reagent for methodological studies in organic chemistry and for exploring new reaction pathways.

Basic Information

Product Name	Proline, 5-Ethenyl-, Ethyl Ester, cis- (9Ci)
CAS No.	112009-96-8
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	cis-5-Vinyl-L-proline ethyl ester; (2S,5S)-5-Ethenylpyrrolidine-2-carboxylic acid ethyl ester; Ethyl (2S,5S)-5-vinylpyrrolidine-2-carboxylate; L-Proline, 5-ethenyl-, ethyl ester, (5S)-; 5-Vinylproline ethyl ester; cis-5-Vinylproline ethyl ester; (S,S)-5-Vinylproline ethyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with typical purity levels suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC/NMR), and specific impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Research Grade)
Specific Rotation	Contact for details
Water Content (KF)	< 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.