Description

tert-Butyldimethylsilyl Propionate is a specialized organosilicon reagent used for the protection of carboxylic acids. This compound is valued for its role in synthetic organic chemistry, particularly in multi-step synthesis where selective protection and deprotection are required. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of active ingredients and complex molecules. The CAS number for this material is 111864-20-1.

Application

• Carboxylic Acid Protection in Peptide Synthesis: Used as a protecting group for the carboxyl terminus or side chains during solid-phase and solution-phase peptide synthesis.
• Intermediate in Pharmaceutical Manufacturing: Serves as a key reagent in the synthesis of complex drug candidates, enabling the selective manipulation of functional groups.
• Agrochemical Synthesis: Employed in the production of advanced herbicides and fungicides where protected carboxylic acid intermediates are necessary.
• Material Science Research: Used in the development of novel polymers and organic electronic materials that require precise molecular architecture.
• Academic & R&D Laboratories: A staple reagent for methodological development and the synthesis of novel organic compounds in research settings.

Basic Information

Product Name	tert-Butyldimethylsilyl Propionate
CAS No.	111864-20-1
Molecular Formula	C9H20O2Si
Molecular Weight	188.34 g/mol
Synonyms	Propanoic acid, 2,2-dimethyl-1-(1,1-dimethylethyl)-1-sila-2-oxacyclopentane; TBDMS Propionate; tert-Butyldimethylsilyl propanoate; 1-(tert-Butyl)-2,2-dimethyl-1-sila-2-oxacyclopentan-3-one; TBDPS Propionate (common misnomer); TBS Propionate; Silicon protecting group reagent
EINECS	Contact for details

Quality Control

Our tert-Butyldimethylsilyl Propionate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the exacting standards of GMP and ISO-guided environments for research and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.