Description

3,6-Di-o-(tert-Butyldimethylsilyl)-D-Glucal is a key protected carbohydrate intermediate, specifically a silyl ether derivative of D-glucal. This compound is essential for synthetic chemists as it provides selective protection of hydroxyl groups, enabling complex multi-step synthesis in a controlled manner. It is primarily used by researchers and manufacturers in the pharmaceutical and fine chemical industries for the development of novel glycosides, nucleoside analogs, and other bioactive molecules. The CAS number for this compound is 111830-53-6.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex carbohydrate-based drugs, antiviral agents, and nucleoside analogs.
• Glycochemistry Research: Used in academic and industrial R&D for studying glycosylation reactions and developing new synthetic methodologies.
• Oligosaccharide Synthesis: Serves as a protected monomer for the controlled, stepwise construction of specific oligosaccharide chains.
• Prodrug Development: Employed to create masked or protected forms of sugar-based active pharmaceutical ingredients (APIs) to improve stability or bioavailability.
• Chiral Pool Synthesis: Utilized as a chiral starting material derived from D-glucose for the asymmetric synthesis of non-carbohydrate natural products.
• Chemical Biology Probes: Acts as a precursor for labeled or modified sugars used to study biological recognition and metabolic pathways.

Basic Information

Product Name	3,6-Di-o-(tert-Butyldimethylsilyl)-D-Glucal
CAS No.	111830-53-6
Molecular Formula	C18H38O5Si2
Molecular Weight	390.67 g/mol
Synonyms	3,6-Di-O-(tert-Butyldimethylsilyl)-1,5-anhydro-2-deoxy-D-arabino-hex-1-enitol; 3,6-Bis-O-(tert-butyldimethylsilyl)-D-glucal; 1,5-Anhydro-2-deoxy-3,6-di-O-[(1,1-dimethylethyl)dimethylsilyl]-D-arabino-hex-1-enitol; D-Glucal, 3,6-bis-O-(1,1-dimethylethyl)dimethylsilyl]-; 3,6-Di-TBDMS-D-glucal; TBDMS-protected D-glucal
EINECS	Contact for details

Quality Control

Our 3,6-Di-o-(tert-Butyldimethylsilyl)-D-Glucal is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical development and research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.