Description

Ethyl 3-Bromo-2,2-Difluoropropionate is a high-purity fluorinated building block essential for advanced organic synthesis. This compound matters for its unique reactivity profile, enabling the efficient introduction of difluoromethyl and bromoalkyl motifs into complex molecular architectures. It is critically needed by R&D and process chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients, particularly in medicinal chemistry for creating protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, including protease and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides with enhanced activity and environmental profile.
• Material Science: Serves as a monomer or precursor for specialty polymers and coatings with unique surface properties.
• Fluorine Chemistry Research: A versatile reagent for studying nucleophilic substitution and coupling reactions involving gem-difluorinated centers.
• Liquid Crystal & OLED Materials: Intermediate in the synthesis of fluorinated components for electronic display materials.
• Cross-Coupling Reactions: Acts as an electrophilic partner in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form C-C bonds.

Basic Information

Product Name	Ethyl 3-Bromo-2,2-Difluoropropionate
CAS No.	111773-24-1
Molecular Formula	C5H7BrF2O2
Molecular Weight	217.01 g/mol
Synonyms	3-Bromo-2,2-difluoropropionic Acid Ethyl Ester; Ethyl 3-Bromo-2,2-difluoropropanoate; 2,2-Difluoro-3-bromopropionic Acid Ethyl Ester; Propanoic acid, 3-bromo-2,2-difluoro-, ethyl ester; Ethyl α,α-difluoro-β-bromopropionate; Bromodifluoropropionic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 3-Bromo-2,2-Difluoropropionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.