Description

5-Chloro-2-Thienylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for constructing complex molecular architectures. Its core value lies in enabling the formation of carbon-carbon bonds, a fundamental transformation in synthetic organic chemistry. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel thiophene-containing compounds.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for creating active pharmaceutical ingredients (APIs) and drug candidates containing the 5-chlorothiophene moiety.
• Agrochemical Development: Used in the research and production of novel herbicides, fungicides, and insecticides where the chlorothienyl group imparts specific biological activity.
• Material Science Research: Employed in the synthesis of organic semiconductors, conductive polymers, and liquid crystals for electronic and optoelectronic applications.
• Fine Chemical Manufacturing: Serves as a versatile reagent for the custom synthesis of specialty chemicals, flavors, and fragrances.
• Academic & R&D Laboratories: A critical tool for methodological development and exploratory synthesis in university and corporate research settings.
• Scale-up Process Chemistry: Suitable for use in pilot plants and manufacturing processes under controlled conditions for the production of kilogram to ton quantities of target molecules.

Basic Information

Product Name	5-Chloro-2-Thienylmagnesium Bromide
CAS No.	111762-30-2
Molecular Formula	C4H2BrClMgS
Molecular Weight	221.78 g/mol
Synonyms	5-Chloro-2-thienylmagnesium bromide solution; 5-Chlorothiophen-2-ylmagnesium bromide; (5-Chlorothiophen-2-yl)magnesium bromide; 2-Thienylmagnesium bromide, 5-chloro-; Magnesium, bromo(5-chloro-2-thienyl)-; Grignard reagent, 5-chloro-2-thienylmagnesium bromide
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Thienylmagnesium Bromide is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analysis, including titration for Grignard concentration and GC analysis of the parent halide. Certificates of Analysis (COA) detailing concentration, solvent, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) at 2-8°C. The solution is typically supplied in a strong acid/organic solvent such as tetrahydrofuran (THF) or diethyl ether. Store away from heat, sparks, open flames, and incompatible materials like water, acids, and oxidizing agents. Use appropriate explosion-proof refrigeration.

Specification

Item	Specification
Appearance	Brown to dark brown solution
Concentration	0.5 M in THF (or as specified)
Assay (Titration)	≥ 95%
Purity (GC, relative to halide)	≥ 98%
Solvent	Tetrahydrofuran (stabilized)
Water Content (Karl Fischer)	≤ 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.