Description

1H-Indene-1-Carboxylicacid,3-Amino-2,3-Dihydro-,Methylester,(1R,3S)-Rel- is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a key building block in the development of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to construct complex molecular architectures.
• Fine Chemical Production: Serves as a precursor in the manufacture of specialty chemicals, agrochemicals, and advanced materials requiring specific stereochemistry.
• Academic & Industrial Research: Employed in chemical research for methodological development and the study of stereoselective transformations.
• Ligand & Catalyst Development: Potential use in the design and synthesis of novel chiral ligands and organocatalysts.

Basic Information

Product Name	1H-Indene-1-Carboxylicacid,3-Amino-2,3-Dihydro-,Methylester,(1R,3S)-Rel-
CAS No.	111634-91-4
Molecular Formula	C11H11NO2
Molecular Weight	189.21 g/mol
Synonyms	(1R,3S)-rel-3-Amino-2,3-dihydro-1H-indene-1-carboxylic acid methyl ester; Methyl (1R,3S)-rel-3-amino-2,3-dihydro-1H-indene-1-carboxylate; rel-(1R,3S)-3-Aminoindane-1-carboxylic acid methyl ester; 3-Amino-2,3-dihydro-1H-indene-1-carboxylic acid methyl ester, (1R,3S)-rel-; Aminoindane carboxylate ester; Chiral indane derivative
EINECS	Contact for details

Quality Control

Our 1H-Indene-1-Carboxylicacid,3-Amino-2,3-Dihydro-,Methylester,(1R,3S)-Rel- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.