Description

5-(-)-Menthyloxycarbonyl-(6S)-Tetrahydrofolate is a high-purity, stereochemically defined derivative of tetrahydrofolic acid, serving as a critical chiral intermediate and reference standard. Its value lies in enabling precise research and development in asymmetric synthesis and biochemical studies where folate cofactor activity is essential. This compound is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on enzymology, oncology research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel folate-based therapeutics and targeted cancer drugs.
• Biochemical Research: Used as a cofactor analog or substrate in enzymatic studies, particularly for investigating folate-dependent enzymes like thymidylate synthase and dihydrofolate reductase.
• Reference Standard: Employed as a high-purity analytical standard for method development, validation, and quality control in HPLC and LC-MS assays.
• Asymmetric Synthesis: Utilized in stereoselective chemical transformations where the menthyloxycarbonyl group acts as a chiral auxiliary or protecting group.
• Nutritional Science Research: Applied in advanced studies on folate metabolism, bioavailability, and the development of specialized nutritional formulations.

Basic Information

Product Name	5-(-)-Menthyloxycarbonyl-(6S)-Tetrahydrofolate
CAS No.	111482-05-4
Molecular Formula	C₃₁H₄₁N₇O₇
Molecular Weight	623.71 g/mol
Synonyms	(6S)-5,6,7,8-Tetrahydrofolic acid 5-(-)-menthyl ester; 5-(-)-Menthyl (6S)-5,6,7,8-tetrahydrofolate; (6S)-THF menthyl ester; L-Menthyl (6S)-tetrahydrofolate; (-)-Menthyloxycarbonyl-(6S)-THF; 5-(-)-Menthyl (6S)-5,6,7,8-tetrahydrofolic acid; 5-(-)-Menthyloxycarbonyl-(6S)-5,6,7,8-tetrahydrofolic acid
EINECS	Contact for details

Quality Control

Our 5-(-)-Menthyloxycarbonyl-(6S)-Tetrahydrofolate is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and related substance profiles. We adhere to cGMP principles for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements for research or development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term stability, the material should be kept in a desiccated environment. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to light brown powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% (6S-isomer)
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.