Description

(2-Nitro-4-Azidophenyl)Deacetylcolchicine is a chemically modified derivative of the natural product colchicine, designed as a specialized biochemical tool. This compound is engineered for advanced research applications, particularly in the study of tubulin dynamics and cellular mechanisms. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and academic institutions engaged in drug discovery and molecular biology.

Application

• Biochemical Research Probe: Used as a photoaffinity labeling agent to study the binding sites and interactions of colchicine with tubulin and other target proteins.
• Medicinal Chemistry & Drug Discovery: Serves as a key intermediate or molecular scaffold in the synthesis and development of novel therapeutic agents targeting cytoskeletal functions.
• Cellular Biology Studies: Employed to investigate microtubule assembly/disassembly, cell division, and mitosis in controlled experimental settings.
• Photochemical Applications: The azido and nitro groups make it suitable for light-activated crosslinking studies in proteomics and structural biology.
• Reference Standard: Used as an analytical standard in quality control and method development for laboratories analyzing colchicine derivatives.

Basic Information

Product Name	(2-Nitro-4-Azidophenyl)Deacetylcolchicine
CAS No.	111348-67-5
Molecular Formula	C28H27N5O6
Molecular Weight	529.55 g/mol
Synonyms	N-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]-2-nitro-4-azidobenzamide; Deacetylcolchicine (2-nitro-4-azidophenyl) Derivative; 2-Nitro-4-azidophenylamide of Deacetylcolchicine; Photoaffinity Colchicine Derivative; Tubulin Photoaffinity Label; Colchicine Photoaffinity Probe; N-(2-Nitro-4-azidobenzoyl)deacetylcolchicine
EINECS	Contact for details

Quality Control

Our (2-Nitro-4-Azidophenyl)Deacetylcolchicine is produced under controlled conditions to ensure high purity and batch-to-batch consistency suitable for research applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and relevant specifications is provided with each batch to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. For long-term storage, keep desiccated under an inert atmosphere. Allow the container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.