Description

Dihydroxy Oxaliplatin-Pt(IV) is a platinum(IV) prodrug derivative of the widely used chemotherapeutic agent oxaliplatin. This compound is designed for enhanced stability and targeted activation, offering a promising approach to improve the therapeutic index and reduce side effects associated with platinum-based cancer treatments. It is a critical intermediate and research chemical for pharmaceutical R&D teams focused on developing next-generation oncology therapeutics and targeted drug delivery systems.

Application

• Pharmaceutical Research & Development: As a key precursor in the synthesis of novel platinum(IV) anticancer prodrugs.
• Oncology Drug Discovery: For studying structure-activity relationships (SAR) and mechanisms of action of platinum complexes.
• Targeted Therapy Development: Serving as a scaffold for conjugation with targeting ligands (e.g., peptides, antibodies) for tumor-specific drug delivery.
• Prodrug Strategy Evaluation: Investigating intracellular reduction mechanisms to release the active platinum(II) species.
• Combination Therapy Studies: Used in research exploring synergistic effects with other anticancer agents.
• Academic & Institutional Research: A vital tool for biochemical and pharmacological studies in university and government laboratories.

Basic Information

Product Name	Dihydroxy Oxaliplatin-Pt(IV)
CAS No.	111321-67-6
Molecular Formula	C8H14N2O8Pt
Molecular Weight	477.30 g/mol
Synonyms	Oxaliplatin Dihydroxide Pt(IV) Complex; (1R,2R)-Cyclohexane-1,2-diamine; Oxalatoplatinum(IV) Dihydroxide; Pt(IV)-Oxaliplatin Dihydroxide; cis-Oxalato(trans-dihydroxo)(1,2-cyclohexanediamine)platinum(IV); Platinum(IV) Oxaliplatin Derivative; Oxaliplatin Prodrug Intermediate; [Pt(IV)(oxalato)(dach)(OH)2]
EINECS	Contact for details

Quality Control

Our Dihydroxy Oxaliplatin-Pt(IV) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We support development work requiring compliance with GMP guidelines for active pharmaceutical ingredient (API) intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.