Description

1-Benzyl-3-(Trimethylsiloxy)Azetidine is a specialized organosilicon-protected azetidine derivative, serving as a versatile and reactive synthetic intermediate. Its core value lies in providing a protected nitrogen scaffold that is crucial for constructing complex molecules in advanced pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists working in medicinal chemistry, particularly for the synthesis of novel bioactive compounds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those containing the azetidine ring system, which is a valuable pharmacophore in modern medicinal chemistry.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the azetidine moiety can contribute to biological activity.
• Organic Synthesis Reagent: Acts as a protected amine equivalent in multi-step synthetic sequences, facilitating reactions that would otherwise be incompatible with a free amine group.
• Ligand and Catalyst Precursor: Employed in the preparation of specialized ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Material Science Research: Potential monomer or modifier in the synthesis of specialty polymers with unique properties.

Basic Information

Product Name	1-Benzyl-3-(Trimethylsiloxy)Azetidine
CAS No.	111043-42-6
Molecular Formula	C13H21NOSi
Molecular Weight	235.40 g/mol
Synonyms	3-(Trimethylsiloxy)-1-benzylazetidine; 1-Benzyl-3-(trimethylsilyloxy)azetidine; Azetidine, 1-benzyl-3-(trimethylsiloxy)-; N-Benzyl-3-(trimethylsiloxy)azetidine; Benzyl(3-(trimethylsilyloxy)azetidin-1-yl)methane; 111043-42-6; 3-(Trimethylsilyloxy)-1-benzylazetidine
EINECS	Contact for details

Quality Control

Our 1-Benzyl-3-(Trimethylsiloxy)Azetidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.