Description

Cyclopropanecarboxylic Acid, 1-Amino-2-Phenyl-, Methyl Ester, (1R-Cis)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its value lies in the unique structural combination of the strained cyclopropane ring and a phenyl-substituted amino ester moiety, which is crucial for constructing complex molecules with specific three-dimensional architectures. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its precise stereochemistry is essential for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the cyclopropane structure can impart unique biological properties and stability.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in the development and testing of new chiral catalysts and synthetic methodologies.
• Peptidomimetics & Bioactive Molecule Design: Incorporated into the backbone of peptide analogs and other bioactive compounds to modulate their conformation, stability, and receptor binding affinity.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions due to its defined stereochemistry and functional handles.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers with potential novel optical or mechanical properties.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 1-Amino-2-Phenyl-, Methyl Ester, (1R-Cis)- (9Ci)
CAS No.	110769-84-1
Molecular Formula	C11H13NO2
Molecular Weight	191.23 g/mol
Synonyms	(1R,2S)-1-Amino-2-phenylcyclopropanecarboxylic acid methyl ester; Methyl (1R,2S)-1-amino-2-phenylcyclopropanecarboxylate; (1R-cis)-1-Amino-2-phenylcyclopropanecarboxylic Acid Methyl Ester; cis-(1R,2S)-1-Amino-2-phenylcyclopropanecarboxylic acid methyl ester; (1R,2S)-1-Amino-2-phenylcyclopropane-1-carboxylic acid methyl ester; (1R,2S)-Amino phenyl cyclopropane carboxylate methyl ester; (1R,2S)-APCC methyl ester
EINECS	Contact for details

Quality Control

Our production of Cyclopropanecarboxylic Acid, 1-Amino-2-Phenyl-, Methyl Ester, (1R-Cis)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized and undergoes rigorous analytical testing, including chiral purity verification, to meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC/GC), enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.