Description

2-Oxa-3-Azabicyclo[2.2.2]Oct-5-Ene-3-Carboxylic Acid, 1,1-Dimethylethyl Ester is a high-value, protected bicyclic amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its rigid, constrained structure is essential for constructing complex molecular architectures with precise stereochemistry. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective agents.
• Peptidomimetic Scaffold: Used to construct conformationally restricted peptide analogs, enhancing metabolic stability and receptor selectivity in therapeutic peptides.
• Ligand Synthesis: Serves as a precursor for sophisticated chiral ligands and catalysts used in asymmetric synthesis, including organocatalysts and transition metal complexes.
• Agrochemical Research: Employed in the development of novel, stereochemically defined pesticides and herbicides with improved efficacy and environmental profiles.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry, enabling studies on cycloaddition reactions and stereoselective transformations.

Basic Information

Product Name	2-Oxa-3-Azabicyclo[2.2.2]Oct-5-Ene-3-Carboxylic Acid, 1,1-Dimethylethyl Ester
CAS No.	110590-29-9
Molecular Formula	C11H17NO3
Molecular Weight	211.26 g/mol
Synonyms	tert-Butyl 2-oxa-3-azabicyclo[2.2.2]oct-5-ene-3-carboxylate; 3-(tert-Butoxycarbonyl)-2-oxa-3-azabicyclo[2.2.2]oct-5-ene; 2-Oxa-3-azabicyclo[2.2.2]oct-5-ene-3-carboxylic acid tert-butyl ester; Bicyclic amino acid tert-butyl ester; Boc-protected 2-oxa-3-azabicyclo[2.2.2]oct-5-ene-3-carboxylate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for assay, chiral purity, and impurity profiles are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and stored away from direct light and moisture sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.