Description

4-(Trimethylsilyl)But-3-Ynoic Acid is a versatile organosilicon building block featuring both a terminal alkyne and a carboxylic acid functional group. This bifunctional nature makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is particularly valuable for scientists and manufacturers in the pharmaceutical, agrochemical, and materials science industries seeking to incorporate silicon-protected alkynes into their target compounds. The CAS number for this compound is 110469-24-4.

Application

This specialized organosilicon reagent is employed in a variety of advanced synthetic pathways, including:

• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating novel molecular scaffolds.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and plant growth regulators that require silicon-containing alkyne motifs.
• Click Chemistry: The terminal alkyne group is ideal for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, enabling efficient bioconjugation and polymer functionalization.
• Materials Science: Acts as a precursor for functionalized polymers, dendrimers, and surface coatings where the carboxylic acid provides an attachment point.
• Organic Synthesis: Used in Sonogashira coupling and other palladium-catalyzed cross-coupling reactions to construct complex organic architectures.
• Protecting Group Strategy: The trimethylsilyl (TMS) group protects the alkyne during multi-step syntheses and can be selectively removed under mild conditions.

Basic Information

Product Name	4-(Trimethylsilyl)But-3-Ynoic Acid
CAS No.	110469-24-4
Molecular Formula	C7H12O2Si
Molecular Weight	156.26 g/mol
Synonyms	4-(Trimethylsilyl)-3-butynoic Acid; 3-Butynoic Acid, 4-(Trimethylsilyl)-; 4-(Trimethylsilyl)but-3-ynoic Acid; TMS-Butynoic Acid; (Trimethylsilyl)ethynylacetic Acid; 4-(Trimethylsilyl)butynoic Acid; 4-(TMS)but-3-ynoic Acid
EINECS	Contact for details

Quality Control

Our 4-(Trimethylsilyl)But-3-Ynoic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FT-IR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage and to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.