Description

L-Proline, 2-Methyl-, Methyl Ester (9Ci) is a high-purity, non-proteinogenic proline derivative that serves as a critical chiral building block in advanced organic synthesis. This compound is valued for its ability to introduce conformational constraints and modify peptide backbone properties, enabling the development of novel bioactive molecules. It is primarily sought by research institutions and pharmaceutical companies engaged in peptide mimetic design, medicinal chemistry, and the development of new therapeutic agents.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used to create constrained peptide analogs with enhanced metabolic stability and receptor selectivity.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore novel chemical space for drug discovery.
• Asymmetric Synthesis: Acts as a chiral auxiliary or building block in stereoselective catalytic reactions.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies related to proline metabolism.
• Agrochemical Development: Potential intermediate in the synthesis of advanced, biologically active crop protection agents.

Basic Information

Product Name	L-Proline, 2-Methyl-, Methyl Ester (9Ci)
CAS No.	109837-32-3
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	Methyl (2S)-2-methylpyrrolidine-2-carboxylate; (2S)-2-Methylpyrrolidine-2-carboxylic acid methyl ester; L-2-Methylproline methyl ester; Methyl L-2-methylprolinate; 2-Methyl-L-proline methyl ester; (S)-2-Methylpyrrolidine-2-carboxylic Acid Methyl Ester; 2-Methylproline Methyl Ester, L-
EINECS	Contact for details

Quality Control

Our L-Proline, 2-Methyl-, Methyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed after use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.