Description

(3R)-3-(tert-Butyldimethylsilyl)Oxypentanedioate-1-Methyl Monoester is a high-purity chiral synthon and protected intermediate of significant value in advanced organic synthesis. Its core value proposition lies in providing a stereochemically defined building block for the efficient construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for chemists in the fine chemical, pharmaceutical, and agrochemical industries who require reliable, high-quality intermediates for asymmetric synthesis and API development.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting specific stereoisomers.
• Asymmetric Synthesis: Used in the construction of complex, stereochemically pure molecules for research and process development.
• Peptidomimetics & Pro-Drug Synthesis: Serves as a protected carboxylic acid derivative for creating peptide analogs and designing pro-drug formulations.
• Natural Product Synthesis: Employed in the total synthesis of natural products where the (R)-configured glutaric acid derivative moiety is required.
• Agrochemical Research: Acts as an intermediate in the development of chiral active ingredients for crop protection agents.
• Material Science: Potential use as a monomer or functionalization agent for creating specialized polymers with tailored properties.

Basic Information

Product Name	(3R)-3-(tert-Butyldimethylsilyl)Oxypentanedioate-1-Methyl Monoester
CAS No.	109744-49-2
Molecular Formula	C12H24O5Si
Molecular Weight	276.41 g/mol
Synonyms	(R)-3-((tert-Butyldimethylsilyl)oxy)pentanedioic acid 1-methyl ester; Methyl (3R)-3-[(tert-butyldimethylsilyl)oxy]glutarate; (R)-Methyl 3-(tert-butyldimethylsiloxy)glutarate; (R)-Mono-methyl 3-(TBDMSO)glutarate; (3R)-3-[(tert-Butyldimethylsilyl)oxy]-1-methoxy-1,5-dioxopentan-1-olate; TBDMS-protected (R)-methyl hydrogen glutarate; Chiral TBDMS-glutaric acid mono-methyl ester.
EINECS	Contact for details

Quality Control

Our (3R)-3-(tert-Butyldimethylsilyl)Oxypentanedioate-1-Methyl Monoester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis (HPLC/GC), to ensure compliance with exacting standards for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly sealed due to the compound's sensitivity to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.