Description

Fmoc-o-tert-Butyl-L-Serine 3,4-Dihydro-4-Oxo-1,2,3-Benzotriazin-3-Yl Ester is a specialized, activated amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound matters as a high-purity building block that enables the efficient and racemization-free incorporation of side-chain protected serine into complex peptide sequences. Pharmaceutical R&D laboratories and fine chemical manufacturers need it for the production of therapeutic peptides, peptidomimetics, and for use in combinatorial chemistry libraries.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the efficient coupling of Fmoc-Ser(tBu)-OH, minimizing racemization risk.
• Pharmaceutical Intermediate: Critical for the research and development of novel therapeutic peptides targeting metabolic diseases, oncology, and infectious diseases.
• Peptidomimetic Design: Used to introduce serine-derived structures with a protected hydroxyl group into non-peptide backbones for enhanced stability and bioavailability.
• Combinatorial Chemistry: Serves as a key building block in the generation of diverse peptide libraries for high-throughput screening and drug discovery.
• Bioconjugation: Employed in the site-specific modification of proteins or other biomolecules where a serine residue with a protected side chain is required.
• Academic & Institutional Research: Used in biochemical and biophysical studies investigating protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR).

Basic Information

Product Name	Fmoc-o-tert-Butyl-L-Serine 3,4-Dihydro-4-Oxo-1,2,3-Benzotriazin-3-Yl Ester
CAS No.	109434-27-7
Molecular Formula	C28H26N4O6
Molecular Weight	514.53 g/mol
Synonyms	Fmoc-Ser(tBu)-ODhbt; N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-serine 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl ester; Fmoc-L-Serine(O-tert-butyl) Dhbt Ester; Fmoc-O-tert-butyl-L-serine Dhbt ester; 3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-serinate; Fmoc-Ser(OtBu)-ODhbt; Dhbt ester of Fmoc-Ser(tBu)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-o-tert-Butyl-L-Serine 3,4-Dihydro-4-Oxo-1,2,3-Benzotriazin-3-Yl Ester is manufactured under strict quality systems suitable for pharmaceutical R&D. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting standards. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to equilibrate to room temperature before opening to minimize condensation and exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% L-isomer
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.