Description

Hydrocinnamic Acid n-Hydroxysuccinimide Ester is a high-purity, bifunctional chemical linker primarily used for the covalent conjugation of biomolecules. This compound matters for its excellent reactivity, enabling the stable and efficient formation of amide bonds under mild aqueous conditions, which is critical for preserving the integrity of sensitive biological structures. It is essential for researchers and manufacturers in the fields of bioconjugation, proteomics, and the development of antibody-drug conjugates (ADCs), diagnostic reagents, and advanced polymer materials.

Application

• Bioconjugation Reagent: For the covalent cross-linking of peptides, proteins, and antibodies to other molecules, surfaces, or polymers.
• Antibody-Drug Conjugate (ADC) Synthesis: Serves as a key linker component for attaching cytotoxic payloads to monoclonal antibodies.
• Diagnostic Assay Development: Used in the preparation of enzyme-labeled antibodies and antigens for ELISA and other immunoassay platforms.
• Polymer Functionalization: Enables the introduction of reactive ester groups onto polymer backbones for subsequent biomolecule immobilization.
• Proteomics Research: A tool for labeling and modifying proteins for mass spectrometry analysis and interaction studies.
• Surface Chemistry: Facilitates the creation of bioactive coatings on chips, beads, and other substrates for biosensor and microarray applications.

Basic Information

Product Name	Hydrocinnamic Acid n-Hydroxysuccinimide Ester
CAS No.	109318-10-7
Molecular Formula	C13H13NO4
Molecular Weight	247.25 g/mol
Synonyms	3-Phenylpropionic Acid N-Hydroxysuccinimide Ester; 3-Phenylpropionyloxy-2,5-pyrrolidinedione; NSC 334368; Hydrocinnamic Acid NHS Ester; N-Hydroxysuccinimide 3-Phenylpropionate; N-Succinimidyl 3-Phenylpropionate; (3-Phenylpropanoyloxy)pyrrolidine-2,5-dione; HCA-NHS
EINECS	Contact for details

Quality Control

Our Hydrocinnamic Acid n-Hydroxysuccinimide Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and biopharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive); desiccate upon opening and minimize exposure to ambient atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.