Description

5-(Hydroxymethyl) Pyridin-2(1H)-One is a versatile heterocyclic building block featuring both a hydroxymethyl group and a lactam moiety on a pyridine ring. This unique bifunctional structure makes it a valuable intermediate for synthesizing complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working in medicinal chemistry and fine chemical manufacturing. The compound's reactivity allows for selective modifications, enabling the construction of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Ligand and Catalyst Precursor: Serves as a starting material for creating specialized ligands used in metal-catalyzed cross-coupling reactions.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new synthetic methodologies and constructing complex molecular architectures.
• Fine Chemical Production: Integrated into multi-step synthesis processes for manufacturing high-value, low-volume specialty chemicals.

Basic Information

Product Name	5-(Hydroxymethyl) Pyridin-2(1H)-One
CAS No.	109205-68-7
Molecular Formula	C6H7NO2
Molecular Weight	125.13 g/mol
Synonyms	5-(Hydroxymethyl)-2-pyridone; 5-(Hydroxymethyl)-2(1H)-pyridinone; 2-Hydroxy-5-(hydroxymethyl)pyridine; 5-Hydroxymethyl-2-pyridone; 2-Pyridinol, 5-(hydroxymethyl)-; 1H-Pyridin-2-one, 5-(hydroxymethyl)-; 5-Hydroxymethylpyridin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 5-(Hydroxymethyl) Pyridin-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP-compliant production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of moisture from the air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.