Description

Fmoc-Pro-Osu CAS NO 109074-94-4 is a high-purity, activated ester derivative of Fmoc-protected proline, specifically designed for efficient peptide synthesis. This compound is a critical reagent for forming peptide bonds under mild conditions, offering superior reactivity and minimal racemization. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research focused on solid-phase and solution-phase peptide synthesis.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the automated, sequential addition of proline residues in peptide chain assembly.
• Solution-Phase Peptide Coupling: Used in classical peptide synthesis where the activated ester facilitates efficient amide bond formation with amino acid or peptide fragments.
• Production of Peptide Therapeutics: Critical for synthesizing peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation and Labeling: Employed to attach proline-containing peptides to other molecules, surfaces, or probes for diagnostic and research applications.
• Combinatorial Chemistry Library Synthesis: Used to create diverse libraries of proline-modified compounds for high-throughput screening in drug discovery.
• Academic and R&D Laboratories: A fundamental reagent for studying peptide structure, function, and for developing novel synthetic methodologies.

Basic Information

Product Name	Fmoc-Pro-Osu
CAS No.	109074-94-4
Molecular Formula	C24H22N2O6
Molecular Weight	434.44 g/mol
Synonyms	Fmoc-Proline N-Hydroxysuccinimide Ester; N-(9-Fluorenylmethoxycarbonyl)-L-proline N-succinimidyl ester; Fmoc-L-Proline OSuc; Fmoc-Pro-OSu; N-α-Fmoc-L-proline succinimidyl ester; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline 2,5-dioxopyrrolidin-1-yl ester; (S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidine-2-carboxylic acid 2,5-dioxopyrrolidin-1-yl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Pro-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, NMR for structural confirmation, and KF for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.