Description

Boc-L-Pyroglutamic Acid Methyl Ester is a protected amino acid derivative widely used as a key chiral building block in organic synthesis. This high-purity intermediate is critical for ensuring the stereochemical integrity and yield of complex target molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of peptide-based therapeutics and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• API Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing pyroglutamic acid motifs.
• Bioconjugation: Serves as a protected linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Research: Employed in the synthesis of probes and inhibitors for studying enzyme mechanisms and protein-protein interactions.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group provides orthogonal protection in multi-step synthetic sequences, allowing for selective deprotection.

Basic Information

Product Name	Boc-L-Pyroglutamic Acid Methyl Ester
CAS No.	108963-96-8
Molecular Formula	C11H17NO5
Molecular Weight	243.26 g/mol
Synonyms	(S)-1-((tert-Butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid methyl ester; Methyl (S)-1-((tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate; Boc-L-pyroGlu-OMe; Boc-L-5-oxoproline methyl ester; L-Pyroglutamic acid, 1-(1,1-dimethylethoxy)carbonyl-, methyl ester; Methyl 1-Boc-5-oxo-L-prolinate; 1-Boc-5-oxo-L-proline methyl ester; (S)-1-Boc-5-oxopyrrolidine-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Boc-L-Pyroglutamic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.