Description

(1R)-1,2,3,4,4A,5,6,8A-Octahydro-8Aα-Isocyano-1α,4Aβ-Dimethyl-7-Propylnaphthalene is a specialized, high-purity isocyanide derivative of a decalin-based sesquiterpene scaffold. This compound matters as a versatile and valuable chiral building block in advanced organic synthesis, particularly for the construction of complex natural product analogs and pharmaceutical intermediates. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce the unique reactivity of the isocyanide functional group into stereochemically defined frameworks.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel therapeutic agents, especially those with terpenoid or steroidal backbones.
• Agrochemical Research: Used in the development of new active ingredients with complex, three-dimensional architectures for crop protection.
• Methodology Development: A valuable substrate in academic and industrial research for developing new catalytic reactions, particularly multi-component reactions (MCRs) involving isocyanides.
• Natural Product Synthesis: Employed as a building block for the total synthesis or structural modification of sesquiterpenes and other natural products.
• Ligand and Catalyst Preparation: Can be utilized to synthesize novel chiral ligands or organocatalysts for asymmetric synthesis.
• Fine Chemical Production: Used in the manufacture of high-value, low-volume specialty chemicals for electronics or advanced materials.

Basic Information

Product Name	(1R)-1,2,3,4,4A,5,6,8A-Octahydro-8Aα-Isocyano-1α,4Aβ-Dimethyl-7-Propylnaphthalene
CAS No.	108648-45-9
Molecular Formula	C₁₆H₂₅N
Molecular Weight	231.38 g/mol
Synonyms	(+)-8α-Isocyano-1α,4β-dimethyl-7-propyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene; (1R,4aS,8aR)-1-Isocyano-1,4a-dimethyl-7-propyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene; 7-Propyl-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-1-isocyanonaphthalene; (1R,4aS,8aR)-8a-Isocyano-1,4a-dimethyl-7-propyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene; Terpene-derived isocyanide; Chiral decalin isocyanide
EINECS	Contact for details

Quality Control

Our (1R)-1,2,3,4,4A,5,6,8A-Octahydro-8Aα-Isocyano-1α,4Aβ-Dimethyl-7-Propylnaphthalene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC and structural confirmation by NMR and IR spectroscopy, to ensure high chemical and isomeric purity suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.