Description

tert-Butyldimethylsilyl Trichloroacetate is a specialized organosilicon reagent primarily used as a versatile protecting group agent in advanced organic synthesis. Its value lies in its ability to selectively protect hydroxyl groups under mild conditions, offering superior stability against a range of subsequent reactions compared to other silylating agents. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries, where precise control over synthetic pathways is critical for developing active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the protection of alcohol functionalities during the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Natural Product and Peptide Chemistry: Used to protect sensitive hydroxyl groups in the synthesis of complex natural products, nucleotides, and peptides, enabling selective reactions at other sites.
• Agrochemical Manufacturing: Employed in the production of advanced pesticides and herbicides where selective protection is required in the synthetic sequence.
• Material Science Research: Serves as a precursor or modifying agent in the development of specialty silicones and functionalized surfaces.
• Process Chemistry & Scale-up: Valued for its robustness and predictability, making it suitable for scaling from laboratory research to pilot plant and commercial manufacturing.
• Academic & R&D Laboratories: A fundamental tool for methodological development in organic synthesis and for constructing molecular libraries for screening.

Basic Information

Product Name	tert-Butyldimethylsilyl Trichloroacetate
CAS No.	108613-05-4
Molecular Formula	C8H13Cl3O2Si
Molecular Weight	275.63 g/mol
Synonyms	TBDMS Trichloroacetate; tert-Butylchlorodimethylsilane Trichloroacetate; Trichloroacetic Acid tert-Butyldimethylsilyl Ester; TBDMS-TCA; (tert-Butyldimethylsilyl) Trichloroacetate; TBS-Trichloroacetate; Siliconizing Reagent TBDMS-TCA; 1,1,1-Trichloro-2-oxo-2-(tert-butyldimethylsilyloxy)ethane
EINECS	Contact for details

Quality Control

Every batch of tert-Butyldimethylsilyl Trichloroacetate is manufactured and tested under strict quality management protocols to ensure consistency and reliability for critical synthetic applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.