Description

5-Hexynoic Acid, Ethyl Ester is a versatile alkyne-containing ester, a valuable building block in organic synthesis and pharmaceutical research. Its terminal alkyne functionality makes it a crucial intermediate for click chemistry, Sonogashira coupling, and other cross-coupling reactions. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates via alkyne-azide cycloaddition (click chemistry).
• Agrochemical Synthesis: Used in the research and development of new pesticides, herbicides, and plant growth regulators.
• Material Science: Building block for polymers, dendrimers, and functionalized surfaces requiring alkyne groups for further modification.
• Organic Synthesis: Essential reagent for Sonogashira, Glaser, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand and Catalyst Development: Precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Fluorescent Probe & Dye Synthesis: Intermediate in the preparation of fluorescent tags and molecular probes for bioimaging and diagnostics.

Basic Information

Product Name	5-Hexynoic Acid, Ethyl Ester
CAS No.	108545-38-6
Molecular Formula	C8H12O2
Molecular Weight	140.18 g/mol
Synonyms	Ethyl 5-Hexynoate; Ethyl 5-Hexynoic Acid Ester; 5-Hexynoic Acid Ethyl Ester; Ethyl Pent-5-ynoate; 5-Hexynoic Acid Ethyl; Ethyl Hex-5-ynoate; Ethyl Pent-1-yn-5-oate
EINECS	Contact for details

Quality Control

Our 5-Hexynoic Acid, Ethyl Ester is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.