Description

6α-Hydroxy Norgestimate is a key pharmaceutical intermediate and metabolite of the progestin norgestimate. This compound is of significant value in the development and quality control of hormonal therapeutics and related research. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the synthesis of steroid-based drugs, analytical method development, and metabolic studies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced steroid-based active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a high-purity standard in analytical laboratories for HPLC, LC-MS, and GC-MS methods to quantify norgestimate and its metabolites.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism, efficacy, and safety profile of norgestimate-containing medications.
• Impurity Profiling: Employed in the identification and quantification of related substances during the drug development and quality assurance processes for hormonal contraceptives.
• Biochemical Research: Serves as a tool compound in studies investigating progesterone receptor interactions and steroid hormone pathways.

Basic Information

Product Name	6α-Hydroxy Norgestimate
CAS No.	108434-19-1
Molecular Formula	C₂₃H₃₁NO₅
Molecular Weight	401.50 g/mol
Synonyms	6α-Hydroxynorgestimate; 17α-Acetoxy-13-ethyl-6α-hydroxy-18,19-dinor-17α-pregn-4-en-20-yn-3-one oxime; 6α-Hydroxy-17α-acetoxy-13-ethyl-18,19-dinor-17α-pregn-4-en-20-yn-3-one oxime; Norgestimate 6α-Hydroxy Metabolite; 6α-OH Norgestimate; (6α,17α)-17-(Acetyloxy)-13-ethyl-6-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one oxime
EINECS	Contact for details

Quality Control

Our 6α-Hydroxy Norgestimate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of specified impurities, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.