Description

4-Bromo-2-(Trimethylsilyl)Thiazole is a high-value organosilicon building block and halogenated heterocycle, crucial for advanced synthetic chemistry. Its core value lies in its dual functionality, where the bromine atom serves as a site for cross-coupling reactions and the trimethylsilyl group acts as a versatile protecting group or a precursor for further functionalization. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require precise intermediates for constructing complex thiazole-containing molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs containing thiazole or modified thiazole cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage the biological activity of halogenated thiazoles.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of advanced organic electronic materials, such as organic semiconductors or light-emitting materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl or complex carbon-carbon bonds.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for catalysis or as a scaffold for metal-organic frameworks (MOFs).
• Organic Synthesis Research: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and constructing molecular libraries.

Basic Information

Product Name	4-Bromo-2-(Trimethylsilyl)Thiazole
CAS No.	108306-53-2
Molecular Formula	C6H10BrNSSi
Molecular Weight	236.21 g/mol
Synonyms	2-(Trimethylsilyl)-4-bromothiazole; 4-Bromo-2-trimethylsilylthiazole; Thiazole, 4-bromo-2-(trimethylsilyl)-; 4-Bromo-2-(trimethylsilyl)-1,3-thiazole; TMS-4-Bromothiazole; 4-Bromo-2-TMS-thiazole; 108306-53-2; 4-Br-2-TMS-Thz
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Trimethylsilyl)Thiazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.