Description

Ethyl 2-Bromo-3,3,3-trifluoropropanoate is a versatile fluorinated building block and alkylating agent of significant interest in advanced organic synthesis. Its core value lies in introducing the pharmacologically important trifluoromethyl group and a reactive bromoester moiety into target molecules, enabling the construction of complex fluorinated compounds. This high-value intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who are developing novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing trifluoromethyl-substituted active pharmaceutical ingredients (APIs), including potential antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Fluorinated Material Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers, liquid crystals, and electronic materials with unique properties.
• Organic Synthesis Reagent: Acts as a versatile reagent for nucleophilic substitution and coupling reactions (e.g., Reformatsky-type reactions) to introduce -CH(CF3)COOEt fragments.
• Life Science Research: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise fluorination at a specific molecular position.

Basic Information

Product Name	Ethyl 2-Bromo-3,3,3-trifluoropropanoate
CAS No.	108221-68-7
Molecular Formula	C5H6BrF3O2
Molecular Weight	223.00 g/mol
Synonyms	2-Bromo-3,3,3-trifluoropropanoic Acid Ethyl Ester; Ethyl 2-Bromo-3,3,3-trifluoropropionate; 3,3,3-Trifluoro-2-bromopropionic Acid Ethyl Ester; Ethyl α-Bromo-β,β,β-trifluoropropionate; 108221-68-7; Bromotrifluoropropionic Acid Ethyl Ester; TFBP-OEt
EINECS	Contact for details

Quality Control

Our Ethyl 2-Bromo-3,3,3-trifluoropropanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its reactivity with strong bases and potential moisture sensitivity, keep the container tightly sealed under an inert atmosphere if specified. Keep away from heat and ignition sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.395 - 1.405
Density (g/mL, 20°C)	1.55 - 1.65

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.