Description

7,7-Difluoroarachidonic Acid is a fluorinated analog of arachidonic acid, a key polyunsaturated fatty acid involved in eicosanoid biosynthesis. This chemical modification introduces fluorine atoms at a specific position, creating a valuable tool compound for biochemical and pharmacological research. It is primarily utilized by researchers in pharmaceutical development, lipidomics, and medicinal chemistry. The compound serves as a critical intermediate for probing enzyme mechanisms and developing novel bioactive molecules.

Application

• Biochemical Research: Used as a substrate or inhibitor in studies of lipoxygenase (LOX) and cyclooxygenase (COX) enzyme pathways to investigate inflammation and signaling mechanisms.
• Medicinal Chemistry: Serves as a key synthetic intermediate for the development of novel fluorinated eicosanoid analogs with potential therapeutic applications.
• Metabolic Pathway Analysis: Employed in lipidomics research to trace and understand the metabolic fate of modified fatty acids within biological systems.
• Pharmaceutical Reference Standard: Acts as a high-purity analytical standard for quality control and method development in drug discovery pipelines.
• Probe Development: Utilized in the creation of activity-based probes for imaging and characterizing lipid-metabolizing enzymes in complex biological samples.

Basic Information

Product Name	7,7-Difluoroarachidonic Acid
CAS No.	108212-65-3
Molecular Formula	C₂₀H₃₀F₂O₂
Molecular Weight	340.45 g/mol
Synonyms	(5Z,8Z,11Z,14Z)-7,7-Difluoroicosa-5,8,11,14-tetraenoic Acid; 7,7-Difluoro-5Z,8Z,11Z,14Z-eicosatetraenoic Acid; 7,7-Difluoro-AA; 7,7-Difluoroarachidonate; Difluoroarachidonic Acid; 7,7-Difluoro-ETA; Fluorinated Arachidonic Acid Analog
EINECS	Contact for details

Quality Control

Our 7,7-Difluoroarachidonic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%
Solubility	Soluble in ethanol, DMSO, DMF; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.