Description

17-Hydroxy-20-Yohimban-16-(n-(4-Azido-3-Iodo)Phenyl)Carboxamide is a complex, heterocyclic organic compound belonging to the yohimbane alkaloid class, functionalized with photoreactive and halogenated aryl groups. This specialized molecule is engineered for advanced research applications, particularly in the development of photoaffinity labeling probes and targeted biochemical tools. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on receptor mapping, enzyme studies, and novel drug discovery platforms.

Application

• Photoaffinity Labeling Probe Development: Serves as a critical intermediate or active probe for covalently tagging and identifying biological targets, such as receptors and enzymes, upon UV light activation.
• Biochemical Research & Receptor Studies: Used in fundamental research to study ligand-receptor interactions, binding sites, and signal transduction pathways due to its yohimbane core structure.
• Medicinal Chemistry & Drug Discovery: Acts as a key synthetic building block for creating novel analogs in the search for new therapeutic agents targeting neurological and cardiovascular systems.
• Chemical Biology Tool Synthesis: Employed in the synthesis of molecular tools for proteomics and chemical genomics to elucidate protein function and cellular mechanisms.
• High-Throughput Screening (HTS): Can be used to develop assay components for screening compound libraries against specific biological targets of interest.

Basic Information

Product Name	17-Hydroxy-20-Yohimban-16-(n-(4-Azido-3-Iodo)Phenyl)Carboxamide
CAS No.	108206-16-2
Molecular Formula	C28H26IN5O2
Molecular Weight	599.45 g/mol
Synonyms	17-Hydroxy-20-yohimban-16-carboxylic acid (4-azido-3-iodophenyl)amide; 16-[(4-Azido-3-iodobenzoyl)amino]-17-hydroxyyohimban; 4-Azido-3-iodo-N-(17-hydroxy-20-yohimban-16-yl)benzamide; Yohimbane azido iodo derivative; Photoaffinity yohimbane probe; CAS 108206-16-2
EINECS	Contact for details

Quality Control

Our 17-Hydroxy-20-Yohimban-16-(n-(4-Azido-3-Iodo)Phenyl)Carboxamide is manufactured under strict quality protocols suitable for research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic identification (NMR, MS), to ensure identity, strength, and composition. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its light-sensitive and easily oxidized nature, this material should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and opened only in low-light conditions. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.