Description

tert-Butyl 4-(Bromomethyl)Benzoate is a versatile and high-purity organic building block, specifically a benzyl bromide derivative protected with a tert-butyl ester group. This compound is valued for its dual functionality, serving as a key intermediate in the synthesis of complex molecules where selective deprotection and further functionalization are required. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing active pharmaceutical ingredients (APIs), ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the bromomethyl group enables efficient coupling to heterocyclic cores.
• Ligand and Catalyst Preparation: Serves as a precursor for phosphine and other donor ligands used in homogeneous catalysis and material science.
• Polymer & Material Science: Incorporated as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, and advanced organic frameworks (MOFs/COFs).
• Chemical Biology & Proteomics: Utilized in the synthesis of activity-based probes (ABPs) and affinity tags for studying enzyme function and protein profiling.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	tert-Butyl 4-(Bromomethyl)Benzoate
CAS No.	108052-76-2
Molecular Formula	C12H15BrO2
Molecular Weight	271.15 g/mol
Synonyms	4-(Bromomethyl)benzoic acid tert-butyl ester; tert-Butyl p-(bromomethyl)benzoate; Benzoic acid, 4-(bromomethyl)-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 4-(bromomethyl)benzoate; p-(Bromomethyl)benzoic acid tert-butyl ester; TBMB; t-Butyl 4-(bromomethyl)benzoate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Bromomethyl)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.