Description

3-Pyridineacetonitrile,α-Hydroxy-,(Alphar)-(9Ci) is a high-purity chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly those with defined stereochemistry, which is critical for developing bioactive molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting neurological and metabolic disorders.
• Agrochemical Synthesis: Used in the preparation of advanced, stereospecific pesticides and herbicides, where the specific spatial orientation of the molecule can enhance efficacy and reduce environmental impact.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis to create enantiomerically pure compounds.
• Fine Chemical Production: Employed in the multistep synthesis of complex, high-value specialty chemicals and flavors & fragrances requiring precise stereochemical control.
• Academic and R&D: A valuable reagent for methodological studies in organic chemistry, enabling new routes for C-C and C-N bond formation with stereoselectivity.

Basic Information

Product Name	3-Pyridineacetonitrile,α-Hydroxy-,(Alphar)-(9Ci)
CAS No.	107986-64-1
Molecular Formula	C8H8N2O
Molecular Weight	148.16 g/mol
Synonyms	(R)-2-Hydroxy-2-(pyridin-3-yl)acetonitrile; (αR)-α-Hydroxy-3-pyridineacetonitrile; 3-Pyridineacetonitrile, α-hydroxy-, (αR)-; (R)-2-Hydroxy-2-(3-pyridyl)acetonitrile; (R)-2-(Pyridin-3-yl)-2-hydroxyacetonitrile; (R)-3-Pyridylglycolonitrile; (R)-2-Hydroxy-2-(3-pyridinyl)ethanenitrile
EINECS	Contact for details

Quality Control

Our 3-Pyridineacetonitrile,α-Hydroxy-,(Alphar)-(9Ci) is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, identity confirmation by IR and NMR spectroscopy, and quantification of key impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.