Description

3-(3-Fluorophenyl)Propenoic Acid, 2-(Diethoxyphosphinyl)-, Ethyl Ester is a specialized organophosphorus compound that serves as a critical building block in advanced organic synthesis. Its molecular architecture, featuring both a fluorinated aromatic ring and a phosphonate ester group, makes it a versatile precursor for creating complex molecules with tailored properties. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas where fluorinated compounds are advantageous.
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides and herbicides, leveraging the fluorine atom for enhanced biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functional additive in the development of specialty polymers, coatings, and advanced materials with specific optical or electronic properties.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and enzyme inhibitors for biochemical research and diagnostic applications.
• Cross-Coupling Reactions: Acts as a Horner-Wadsworth-Emmons (HWE) reagent or related phosphonate for olefination reactions to construct complex alkenes.
• Ligand & Catalyst Development: Utilized as a starting material for synthesizing novel phosphonate-based ligands for metal catalysis.

Basic Information

Product Name	3-(3-Fluorophenyl)Propenoic Acid, 2-(Diethoxyphosphinyl)-, Ethyl Ester
CAS No.	107846-68-4
Molecular Formula	C15H20FO5P
Molecular Weight	330.29 g/mol
Synonyms	Ethyl 2-(Diethoxyphosphoryl)-3-(3-fluorophenyl)acrylate; Ethyl (2E)-2-(Diethoxyphosphoryl)-3-(3-fluorophenyl)prop-2-enoate; Diethyl [(1E)-2-Ethoxy-2-oxo-1-(3-fluorophenyl)ethenyl]phosphonate; 3-(3-Fluorophenyl)-2-(phosphono)acrylic Acid Diethyl Ester; (E)-Ethyl 3-(3-fluorophenyl)-2-(phosphono)acrylate Diethyl Ester; Diethyl (E)-[2-Ethoxy-1-(3-fluorophenyl)-2-oxoethenyl]phosphonate; A phosphonate acrylate fluorophenyl derivative
EINECS	Contact for details

Quality Control

Our production of 3-(3-Fluorophenyl)Propenoic Acid, 2-(Diethoxyphosphinyl)-, Ethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is compatible with strong bases and organic solvents but should be kept away from incompatible materials. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E/Z Ratio)	≥ 95:5 (E-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.